Saturday, June 28, 2025

This $60 3D-printed Raspberry Pi microscope captures sub-cellular particulars with superb readability


In context: 3D printing is slowly changing into mainstream, having moved past purposeful prototyping, fast tooling, trinkets, and toys. We’ve already seen folks use 3D printers to create trend merchandise, high-performance automotive components, and even robotic prosthetics for people and animals. Researchers have now used the expertise to construct a completely functioning optical microscope for simply $60.

Researchers on the College of Strathclyde in Glasgow, Scotland, constructed the microscope utilizing OpenFlexure’s open-source design, which is freely accessible on-line.

The crew used a Raspberry Pi to manage the system, including an off-the-shelf digicam and a lightweight supply to craft what they declare is the world’s first fully 3D-printed purposeful microscope for histological imaging.

With all of the parts, the microscope weighs round 3 kg, or 6.6 lbs. In keeping with New Scientist, the machine took solely 3 hours to construct from the bottom up, at a value of simply £50 (round $60).

The researchers programmed a Mars 3 Professional 3D printer to construct a budget plastic lenses utilizing a photopolymerizing clear resin. They have been designed to satisfy the precise specs of the Edmund Optics 12.7 mm diameter plano-convex lens with a 35 mm focal size, and value a fraction of the costly glass lenses historically utilized in highly effective microscopes.

The crew examined the 3D-printed microscope with a blood smear and a tissue pattern from a mouse kidney. The magnified picture had a subject view of 1.7 mm with a single cell spatial decision of round 5 micrometers. It clearly depicted important sub-cellular anatomical particulars, similar to renal tubules. It is a main step up from earlier DIY Raspberry Pi microscopes, which could not see sub-cellular particulars with the identical diploma of readability.

Through the years, researchers and DIY hobbyists have assembled microscopes utilizing OpenFlexture’s open-source blueprints in over 50 international locations around the globe, together with laboratories in Antarctica. Nevertheless, these gadgets want customized glass lenses costing a whole bunch of {dollars}, making them too costly for a lot of use instances.

The College of Strathclyde crew developed a workaround that drastically reduce the overall value of the machine, doubtlessly democratizing microscopes for researchers on a shoestring funds. The researchers consider that their revolutionary design will pave the best way for extra superior fashions with higher-powered lenses providing different apertures and magnifications.

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